Assay Detail
Binding
CHEMBL4275769
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Competitive inhibition of human liver ACLY using varying levels of citrate as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.83 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165262 | — | — | 1 | 6.16 |
| CHEMBL2165261 | — | — | 1 | 5.50 |
| CHEMBL118715 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165262 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL2165261 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL118715 | — | Ki | = | 300000.0 | nM | - |