Assay Detail
Binding
CHEMBL4276207
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Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells after 15 to 20 mins by microbeta scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and systematic evaluation of 4-arylpiperazine- and 4-benzylpiperidine napthyl ethers as inhibitors of monoamine neurotransmitters reuptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.05 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288240 | — | — | 1 | 6.09 |
| CHEMBL4082902 | — | — | 1 | 6.01 |
| CHEMBL4245867 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288240 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4082902 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4245867 | — | IC50 | > | 10000.0 | nM | - |