Assay Detail
Functional
CHEMBL4276511
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Antiviral activity against Influenza A virus (A/Wisconsin/67/2005(H3N2)) infected in MDCK cells after 2 days by plaque reduction assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Wisconsin/67/2005(H3N2)) |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.17 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 6.52 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 5.92 |
| CHEMBL4287425 | — | — | 1 | 4.15 |
| CHEMBL4276773 | — | — | 1 | 4.10 |
| CHEMBL4292576 | — | — | 1 | - |
| CHEMBL4285398 | — | — | 1 | - |
| CHEMBL4292761 | — | — | 1 | - |
| CHEMBL4285029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4287425 | — | EC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4276773 | — | EC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL4292576 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4285398 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4292761 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4285029 | — | EC50 | > | 100000.0 | nM | - |