Assay Detail
Binding
CHEMBL4276515
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus A/goose/Guangdong/SH7/2013(H5N1) neuraminidase N1 using fluorogenic MUNANA as substrate preincubated for 10 mins followed by substrate addition measured after 40 to 60 mins by fluorescence-based assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.12 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287425 | — | — | 1 | 9.02 |
| CHEMBL4276773 | — | — | 1 | 8.42 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.11 |
| CHEMBL4292576 | — | — | 1 | 7.69 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.58 |
| CHEMBL4282553 | — | — | 1 | 7.43 |
| CHEMBL4285767 | — | — | 1 | 7.20 |
| CHEMBL4278505 | — | — | 1 | 7.20 |
| CHEMBL4281970 | — | — | 1 | 6.58 |
| CHEMBL4285398 | — | — | 1 | 5.98 |
| CHEMBL4285029 | — | — | 1 | 5.93 |
| CHEMBL4288395 | — | — | 1 | 5.75 |
| CHEMBL4292761 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287425 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL4276773 | — | IC50 | = | 3.83 | nM | 8.42 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 7.77 | nM | 8.11 |
| CHEMBL4292576 | — | IC50 | = | 20.45 | nM | 7.69 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 26.63 | nM | 7.58 |
| CHEMBL4282553 | — | IC50 | = | 37.31 | nM | 7.43 |
| CHEMBL4285767 | — | IC50 | = | 63.89 | nM | 7.20 |
| CHEMBL4278505 | — | IC50 | = | 63.87 | nM | 7.20 |
| CHEMBL4281970 | — | IC50 | = | 266.33 | nM | 6.58 |
| CHEMBL4285398 | — | IC50 | = | 1050.37 | nM | 5.98 |
| CHEMBL4285029 | — | IC50 | = | 1179.33 | nM | 5.93 |
| CHEMBL4288395 | — | IC50 | = | 1795.33 | nM | 5.75 |
| CHEMBL4292761 | — | IC50 | = | 2023.67 | nM | 5.69 |