Assay Detail
Binding
CHEMBL4276516
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Inhibition of Influenza A virus A/Chicken/Hebei/LZF/2014(H5N2) neuraminidase N2 using fluorogenic MUNANA as substrate preincubated for 10 mins followed by substrate addition measured after 40 to 60 mins by fluorescence-based assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.38 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.31 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.00 |
| CHEMBL4288395 | — | — | 1 | 6.56 |
| CHEMBL4292761 | — | — | 1 | 6.40 |
| CHEMBL4285029 | — | — | 1 | 6.27 |
| CHEMBL4287425 | — | — | 1 | 6.05 |
| CHEMBL4285767 | — | — | 1 | 6.01 |
| CHEMBL4278505 | — | — | 1 | 5.98 |
| CHEMBL4281970 | — | — | 1 | 5.95 |
| CHEMBL4276773 | — | — | 1 | 5.94 |
| CHEMBL4285398 | — | — | 1 | 5.91 |
| CHEMBL4282553 | — | — | 1 | 5.80 |
| CHEMBL4292576 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 4.85 | nM | 8.31 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 10.04 | nM | 8.00 |
| CHEMBL4288395 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL4292761 | — | IC50 | = | 398.5 | nM | 6.40 |
| CHEMBL4285029 | — | IC50 | = | 541.27 | nM | 6.27 |
| CHEMBL4287425 | — | IC50 | = | 896.9 | nM | 6.05 |
| CHEMBL4285767 | — | IC50 | = | 965.83 | nM | 6.01 |
| CHEMBL4278505 | — | IC50 | = | 1046.03 | nM | 5.98 |
| CHEMBL4281970 | — | IC50 | = | 1112.87 | nM | 5.95 |
| CHEMBL4276773 | — | IC50 | = | 1154.5 | nM | 5.94 |
| CHEMBL4285398 | — | IC50 | = | 1243.0 | nM | 5.91 |
| CHEMBL4282553 | — | IC50 | = | 1595.67 | nM | 5.80 |
| CHEMBL4292576 | — | IC50 | = | 1649.0 | nM | 5.78 |