Assay Detail
Binding
CHEMBL4276583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-mepyramine from histamine H1 receptor in guinea pig cerebellum homogenates incubated for 60 mins by liquid scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.65 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290311 | — | — | 1 | 7.36 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.33 |
| CHEMBL4294799 | — | — | 1 | 6.47 |
| CHEMBL4289498 | — | — | 1 | 6.38 |
| CHEMBL4293999 | — | — | 1 | 6.20 |
| CHEMBL4283548 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290311 | — | Ki | = | 43.5 | nM | 7.36 |
| CHEMBL85 | RISPERIDONE | Ki | = | 46.2 | nM | 7.33 |
| CHEMBL4294799 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL4289498 | — | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL4293999 | — | Ki | = | 630.3 | nM | 6.20 |
| CHEMBL4283548 | — | Ki | = | 711.7 | nM | 6.15 |