Assay Detail
Binding
CHEMBL4276587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H] 7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle homogenates after 60 mins by liquid scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.50 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4293999 | — | — | 1 | 8.78 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.50 |
| CHEMBL4294799 | — | — | 1 | 7.34 |
| CHEMBL4283548 | — | — | 1 | 7.26 |
| CHEMBL4289498 | — | — | 1 | 7.21 |
| CHEMBL4290311 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4293999 | — | Ki | = | 1.66 | nM | 8.78 |
| CHEMBL85 | RISPERIDONE | Ki | = | 31.9 | nM | 7.50 |
| CHEMBL4294799 | — | Ki | = | 45.37 | nM | 7.34 |
| CHEMBL4283548 | — | Ki | = | 54.9 | nM | 7.26 |
| CHEMBL4289498 | — | Ki | = | 61.3 | nM | 7.21 |
| CHEMBL4290311 | — | Ki | = | 116.32 | nM | 6.93 |