Assay Detail
Toxicity
CHEMBL4303779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
hERG binding assays: Displacement of [3H]-Dofetilide (5 nM final) from hERG membranes obtained from HEK293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cell membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.78 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1626 | CLEMASTINE | 4.0 | 1 | 6.80 |
| CHEMBL53325 | — | — | 1 | 6.00 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | 5.60 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.50 |
| CHEMBL4088272 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1626 | CLEMASTINE | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL53325 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL76 | CHLOROQUINE | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL4088272 | — | Ki | = | 10000.0 | nM | 5.00 |