Assay Detail
Binding
CHEMBL4305404
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Binding affinity to MET in CD-1 mouse cochlear outer hair cells measured at +96 mV membrane potential by patch clamp assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 5.80 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 5.82 |
| CHEMBL4513932 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL723 | CARVEDILOL | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL4513932 | — | Kd | = | 1700.0 | nM | 5.77 |