Assay Detail
Binding
CHEMBL4305437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of biotinylated AVPF from N-terminal His tagged recombinant human XIAP-BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21(DE3) cells incubated for 8 hrs by DELFIA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.48 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443905 | — | — | 1 | 8.46 |
| CHEMBL4475136 | — | — | 1 | 8.10 |
| CHEMBL4277819 | — | — | 1 | 7.89 |
| CHEMBL2063869 | GDC-0152 | 1.0 | 1 | 7.68 |
| CHEMBL4545874 | — | — | 1 | 7.62 |
| CHEMBL4437401 | — | — | 1 | 7.55 |
| CHEMBL4283320 | — | — | 1 | 7.41 |
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 7.28 |
| CHEMBL4555169 | — | — | 1 | 7.19 |
| CHEMBL4462680 | — | — | 1 | 7.05 |
| CHEMBL4464994 | — | — | 1 | 7.00 |
| CHEMBL4437384 | — | — | 1 | 7.00 |
| CHEMBL4472035 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443905 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4475136 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4277819 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2063869 | GDC-0152 | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4545874 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4437401 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4283320 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2431768 | LCL-161 | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4555169 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4462680 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4464994 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4437384 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4472035 | — | IC50 | = | 105.0 | nM | 6.98 |