Assay Detail
Binding
CHEMBL4305458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of biotinylated AVPF from N-terminal His tagged recombinant human XIAP-BIR3 Lys311Ser mutant expressed in Escherichia coli BL21(DE3) cells incubated for 2 hrs by DELFIA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.62 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475136 | — | — | 1 | 6.84 |
| CHEMBL4277819 | — | — | 1 | 6.80 |
| CHEMBL4545874 | — | — | 1 | 6.75 |
| CHEMBL4472035 | — | — | 1 | 6.62 |
| CHEMBL4462680 | — | — | 1 | 6.60 |
| CHEMBL4464994 | — | — | 1 | 6.60 |
| CHEMBL4437384 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475136 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4277819 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4545874 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4472035 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL4462680 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4464994 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4437384 | — | IC50 | = | 713.0 | nM | 6.15 |