Assay Detail
Functional
CHEMBL4305486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human SKOV3 cells assessed caspase-3 activation after 48 hrs by IncuCyte S3 live-cell analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.96 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 9.00 |
| CHEMBL2063869 | GDC-0152 | 1.0 | 1 | 8.60 |
| CHEMBL4437401 | — | — | 1 | 8.40 |
| CHEMBL4443905 | — | — | 1 | 7.30 |
| CHEMBL4555169 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2063869 | GDC-0152 | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4437401 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4443905 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4555169 | — | EC50 | = | 300.0 | nM | 6.52 |