Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4305654

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of yeast alpha-glucosidase using p-nitrophenyl-alpha-d-glucopyranoside as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview.
Dhameja M, Gupta P.
Eur J Med Chem (2019) 176 : 343 -377
PubMed 31112894 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.84 6.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4544953 1 6.21
CHEMBL4475955 1 6.10
CHEMBL4542148 1 5.44
CHEMBL4516081 1 5.19
CHEMBL4589183 1 5.17
CHEMBL4456023 1 4.92
CHEMBL4462294 1 4.55
CHEMBL4286719 1 4.27
CHEMBL4447063 1 4.22
CHEMBL4437320 1 4.22
CHEMBL4534759 1 4.22
CHEMBL4293535 1 4.22
CHEMBL4526906 1 4.14
CHEMBL404271 ACARBOSE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4544953 IC50 = 610.0 nM 6.21
CHEMBL4475955 IC50 = 800.0 nM 6.10
CHEMBL4542148 IC50 = 3600.0 nM 5.44
CHEMBL4516081 IC50 = 6500.0 nM 5.19
CHEMBL4589183 IC50 = 6800.0 nM 5.17
CHEMBL4456023 IC50 = 12000.0 nM 4.92
CHEMBL4462294 IC50 = 28000.0 nM 4.55
CHEMBL4286719 IC50 = 54000.0 nM 4.27
CHEMBL4447063 IC50 = 60000.0 nM 4.22
CHEMBL4437320 IC50 = 60000.0 nM 4.22
CHEMBL4534759 IC50 = 60000.0 nM 4.22
CHEMBL4293535 IC50 = 60000.0 nM 4.22
CHEMBL4526906 IC50 = 73000.0 nM 4.14
CHEMBL404271 ACARBOSE IC50 = 937000.0 nM -