Assay Detail
Functional
CHEMBL4305759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Dengue virus 2 New Guinea C infected in human HuH7 cells assessed as reduction in viral infection measured at 48 hrs post infection by renilla-luciferase substrate based assay
58
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.41 | 6.14 |
| EC90 | 29 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439128 | — | — | 2 | 6.14 |
| CHEMBL4474078 | — | — | 2 | 5.97 |
| CHEMBL535 | SUNITINIB | 4.0 | 2 | 5.87 |
| CHEMBL4541962 | — | — | 2 | 5.79 |
| CHEMBL4529052 | — | — | 2 | 5.68 |
| CHEMBL4455428 | — | — | 2 | 5.58 |
| CHEMBL4561278 | — | — | 2 | 5.53 |
| CHEMBL3102941 | — | — | 2 | 5.52 |
| CHEMBL4456500 | — | — | 2 | 5.52 |
| CHEMBL4442812 | — | — | 2 | 5.48 |
| CHEMBL4475520 | — | — | 2 | 5.47 |
| CHEMBL4444527 | — | — | 2 | 5.39 |
| CHEMBL4468845 | — | — | 2 | 5.38 |
| CHEMBL3334981 | — | — | 2 | 5.37 |
| CHEMBL4450261 | — | — | 2 | 5.36 |
| CHEMBL4483684 | — | — | 2 | 5.31 |
| CHEMBL4590585 | — | — | 2 | 5.28 |
| CHEMBL4461527 | — | — | 2 | 5.25 |
| CHEMBL4453393 | — | — | 2 | 5.19 |
| CHEMBL4449852 | — | — | 2 | 5.13 |
| CHEMBL4476807 | — | — | 2 | 5.09 |
| CHEMBL4524476 | — | — | 2 | 5.08 |
| CHEMBL516312 | — | — | 2 | 5.08 |
| CHEMBL4448513 | — | — | 2 | 4.99 |
| CHEMBL4515873 | — | — | 2 | 4.90 |
| CHEMBL4553067 | — | — | 2 | - |
| CHEMBL4443908 | — | — | 2 | - |
| CHEMBL4454007 | — | — | 2 | - |
| CHEMBL4471240 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439128 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4474078 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL535 | SUNITINIB | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4541962 | — | EC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4529052 | — | EC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL4455428 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4561278 | — | EC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL3102941 | — | EC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4456500 | — | EC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL4442812 | — | EC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL4475520 | — | EC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL4444527 | — | EC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL4468845 | — | EC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL3334981 | — | EC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL4450261 | — | EC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL4483684 | — | EC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL4590585 | — | EC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL4461527 | — | EC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL4453393 | — | EC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL4449852 | — | EC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL4476807 | — | EC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL4524476 | — | EC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL516312 | — | EC50 | = | 8370.0 | nM | 5.08 |
| CHEMBL4448513 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4515873 | — | EC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL535 | SUNITINIB | EC90 | = | 2.71 | uM | - |
| CHEMBL516312 | — | EC90 | = | 46.8 | uM | - |
| CHEMBL4590585 | — | EC90 | = | 87.1 | uM | - |
| CHEMBL4453393 | — | EC90 | = | 25.2 | uM | - |
| CHEMBL4561278 | — | EC90 | = | 12.0 | uM | - |
| CHEMBL4450261 | — | EC90 | = | 25.8 | uM | - |
| CHEMBL4455428 | — | EC90 | = | 33.6 | uM | - |
| CHEMBL4483684 | — | EC90 | = | 10.8 | uM | - |
| CHEMBL4541962 | — | EC90 | = | 7.46 | uM | - |
| CHEMBL4456500 | — | EC90 | = | 66.8 | uM | - |
| CHEMBL4474078 | — | EC90 | = | 3.73 | uM | - |
| CHEMBL4444527 | — | EC90 | = | 50.5 | uM | - |
| CHEMBL4448513 | — | EC90 | = | 41.2 | uM | - |
| CHEMBL4449852 | — | EC90 | = | 20.5 | uM | - |
| CHEMBL4454007 | — | EC90 | - | — | - | |
| CHEMBL4454007 | — | EC50 | - | — | - | |
| CHEMBL4439128 | — | EC90 | = | 4.16 | uM | - |
| CHEMBL4471240 | — | EC50 | - | — | - | |
| CHEMBL4471240 | — | EC90 | - | — | - | |
| CHEMBL4476807 | — | EC90 | = | 106.0 | uM | - |
| CHEMBL4529052 | — | EC90 | = | 19.0 | uM | - |
| CHEMBL4461527 | — | EC90 | = | 10.58 | uM | - |
| CHEMBL4442812 | — | EC90 | = | 7.68 | uM | - |
| CHEMBL4468845 | — | EC90 | = | 8.57 | uM | - |
| CHEMBL4553067 | — | EC90 | - | — | - |