Assay Detail
Binding
CHEMBL4306771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RIP1 in cynomolgus monkey whole blood assessed as inhibition of TNF-alpha/QVD-Oph/RMT5265-stimulated IL-1 beta cytokine overproduction incubated for 6 hrs by sandwich ELISA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca fascicularis |
| Tissue | Blood |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.80 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4452233 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4452233 | — | IC50 | = | 16.0 | nM | 7.80 |