Assay Detail
Functional
CHEMBL4307007
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Cytotoxicity against human OVCAR8 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.73 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435124 | — | — | 1 | 6.64 |
| CHEMBL3137336 | UPROSERTIB | 2.0 | 1 | 6.27 |
| CHEMBL4545734 | — | — | 1 | 6.24 |
| CHEMBL4460688 | — | — | 1 | 6.19 |
| CHEMBL4438248 | — | — | 1 | 5.86 |
| CHEMBL4454791 | — | — | 1 | 5.83 |
| CHEMBL4445702 | — | — | 1 | 5.80 |
| CHEMBL4579551 | — | — | 1 | 5.76 |
| CHEMBL4526242 | — | — | 1 | 5.60 |
| CHEMBL4554198 | — | — | 1 | 5.57 |
| CHEMBL4467970 | — | — | 1 | 5.50 |
| CHEMBL4442226 | — | — | 1 | 5.25 |
| CHEMBL4455194 | — | — | 1 | 5.14 |
| CHEMBL4577134 | — | — | 1 | 4.55 |
| CHEMBL4461200 | — | — | 1 | - |
| CHEMBL4444441 | — | — | 1 | - |
| CHEMBL2219422 | AFURESERTIB | 3.0 | 1 | - |
| CHEMBL4451854 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435124 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3137336 | UPROSERTIB | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4545734 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4460688 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4438248 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4454791 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4445702 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4579551 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4526242 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL4554198 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4467970 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL4442226 | — | IC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL4455194 | — | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL4577134 | — | IC50 | = | 27990.0 | nM | 4.55 |
| CHEMBL4461200 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4444441 | — | IC50 | - | — | - | |
| CHEMBL2219422 | AFURESERTIB | IC50 | - | — | - | |
| CHEMBL4451854 | — | IC50 | - | — | - |