Assay Detail
Functional
CHEMBL4307010
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Antiproliferative activity against human RPMI8226 cells assessed as reduction in cell viability
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.72 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451854 | — | — | 1 | 7.31 |
| CHEMBL4435124 | — | — | 1 | 6.58 |
| CHEMBL3137336 | UPROSERTIB | 2.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451854 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4435124 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL3137336 | UPROSERTIB | IC50 | = | 538.0 | nM | 6.27 |