Assay Detail
Binding
CHEMBL4307144
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARalpha (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor α/δ Agonist for the Treatment of Primary Biliary Cirrhosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.46 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21241 | GW7647 | — | 1 | 8.30 |
| CHEMBL4470753 | — | — | 1 | 8.10 |
| CHEMBL4436335 | — | — | 1 | 7.57 |
| CHEMBL3707395 | ELAFIBRANOR | 4.0 | 1 | 6.65 |
| CHEMBL4516239 | — | — | 1 | 6.42 |
| CHEMBL4566817 | — | — | 1 | 5.55 |
| CHEMBL4460024 | — | — | 1 | 5.47 |
| CHEMBL4483327 | — | — | 1 | 5.05 |
| CHEMBL4587533 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21241 | GW7647 | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4470753 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4436335 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3707395 | ELAFIBRANOR | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL4516239 | — | EC50 | = | 385.0 | nM | 6.42 |
| CHEMBL4566817 | — | EC50 | = | 2821.0 | nM | 5.55 |
| CHEMBL4460024 | — | EC50 | = | 3423.0 | nM | 5.47 |
| CHEMBL4483327 | — | EC50 | = | 8974.0 | nM | 5.05 |
| CHEMBL4587533 | — | EC50 | = | 10000.0 | nM | 5.00 |