Assay Detail
Binding
CHEMBL4307146
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARgamma (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Novel Selective Dual Peroxisome Proliferator-Activated Receptor α/δ Agonist for the Treatment of Primary Biliary Cirrhosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.05 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 6.67 |
| CHEMBL4436335 | — | — | 1 | 6.34 |
| CHEMBL3707395 | ELAFIBRANOR | 4.0 | 1 | 5.67 |
| CHEMBL4470753 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408 | TROGLITAZONE | EC50 | = | 215.0 | nM | 6.67 |
| CHEMBL4436335 | — | EC50 | = | 457.0 | nM | 6.34 |
| CHEMBL3707395 | ELAFIBRANOR | EC50 | = | 2116.0 | nM | 5.67 |
| CHEMBL4470753 | — | EC50 | = | 2939.0 | nM | 5.53 |