Assay Detail
Binding
CHEMBL4307196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation counting method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; GRIN1/GRIN2B (CHEMBL1907603) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.65 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4581662 | — | — | 1 | 8.70 |
| CHEMBL4533030 | — | — | 1 | 8.30 |
| CHEMBL4459690 | — | — | 1 | 8.30 |
| CHEMBL4446466 | — | — | 1 | 8.09 |
| CHEMBL4449269 | — | — | 1 | 8.09 |
| CHEMBL4445874 | — | — | 1 | 8.00 |
| CHEMBL4439170 | — | — | 1 | 7.92 |
| CHEMBL4451677 | — | — | 1 | 7.64 |
| CHEMBL4446431 | — | — | 1 | 7.58 |
| CHEMBL4446009 | — | — | 1 | 7.57 |
| CHEMBL4463741 | — | — | 1 | 7.24 |
| CHEMBL4567801 | — | — | 1 | 7.17 |
| CHEMBL4453315 | — | — | 1 | 7.11 |
| CHEMBL4442750 | — | — | 1 | 6.65 |
| CHEMBL4454333 | — | — | 1 | 6.38 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4581662 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4533030 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4459690 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4446466 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL4449269 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL4445874 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4439170 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4451677 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4446431 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4446009 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL4463741 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL4567801 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL4453315 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL4442750 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL4454333 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL54 | HALOPERIDOL | Ki | - | — | - | |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | - | — | - |