Assay Detail
ADMET
CHEMBL4307482
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Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins to 2 hrs by phenol red dye based stopped flow CO2 hydrase assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.07 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL4539935 | — | — | 1 | 6.76 |
| CHEMBL4558585 | — | — | 1 | 6.54 |
| CHEMBL4575821 | — | — | 1 | 6.47 |
| CHEMBL4464046 | — | — | 1 | 6.47 |
| CHEMBL4530524 | — | — | 1 | 6.27 |
| CHEMBL4539159 | — | — | 1 | 6.04 |
| CHEMBL4520305 | — | — | 1 | 5.77 |
| CHEMBL4474840 | — | — | 1 | 5.64 |
| CHEMBL4540966 | — | — | 1 | 5.63 |
| CHEMBL4542829 | — | — | 1 | 5.59 |
| CHEMBL4466186 | — | — | 1 | 5.41 |
| CHEMBL4532459 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4539935 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL4558585 | — | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL4575821 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL4464046 | — | Ki | = | 342.0 | nM | 6.47 |
| CHEMBL4530524 | — | Ki | = | 541.0 | nM | 6.27 |
| CHEMBL4539159 | — | Ki | = | 908.0 | nM | 6.04 |
| CHEMBL4520305 | — | Ki | = | 1714.0 | nM | 5.77 |
| CHEMBL4474840 | — | Ki | = | 2275.0 | nM | 5.64 |
| CHEMBL4540966 | — | Ki | = | 2344.0 | nM | 5.63 |
| CHEMBL4542829 | — | Ki | = | 2581.0 | nM | 5.59 |
| CHEMBL4466186 | — | Ki | = | 3930.0 | nM | 5.41 |
| CHEMBL4532459 | — | Ki | = | 39300.0 | nM | 4.41 |