Assay Detail
Binding
CHEMBL4307485
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Inhibition of human carbonic anhydrase 12 assessed as reduction in CO2 hydration preincubated for 15 mins to 2 hrs by phenol red dye based stopped flow CO2 hydrase assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.61 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.60 |
| CHEMBL4539935 | — | — | 1 | 7.23 |
| CHEMBL4530524 | — | — | 1 | 7.09 |
| CHEMBL4558585 | — | — | 1 | 7.05 |
| CHEMBL4575821 | — | — | 1 | 6.90 |
| CHEMBL4540966 | — | — | 1 | 6.74 |
| CHEMBL4464046 | — | — | 1 | 6.39 |
| CHEMBL4532459 | — | — | 1 | 6.28 |
| CHEMBL4539159 | — | — | 1 | 6.18 |
| CHEMBL4542829 | — | — | 1 | 6.09 |
| CHEMBL4474840 | — | — | 1 | 6.08 |
| CHEMBL4466186 | — | — | 1 | 5.79 |
| CHEMBL4520305 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL4539935 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL4530524 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL4558585 | — | Ki | = | 89.6 | nM | 7.05 |
| CHEMBL4575821 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL4540966 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL4464046 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL4532459 | — | Ki | = | 528.0 | nM | 6.28 |
| CHEMBL4539159 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL4542829 | — | Ki | = | 811.0 | nM | 6.09 |
| CHEMBL4474840 | — | Ki | = | 822.0 | nM | 6.08 |
| CHEMBL4466186 | — | Ki | = | 1623.0 | nM | 5.79 |
| CHEMBL4520305 | — | Ki | = | 2982.0 | nM | 5.53 |