Assay Detail
Binding
CHEMBL4307489
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Inhibition of recombinant human DPPI using H-Gly-Arg-AFC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorescence plate reader analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.83 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4561264 | — | — | 1 | 9.40 |
| CHEMBL4579467 | — | — | 1 | 8.80 |
| CHEMBL4513306 | — | — | 1 | 8.20 |
| CHEMBL4570759 | — | — | 1 | 7.30 |
| CHEMBL4451898 | — | — | 1 | 7.10 |
| CHEMBL4461966 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4561264 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL4579467 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4513306 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4570759 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4451898 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4461966 | — | IC50 | = | 630.96 | nM | 6.20 |