Assay Detail
Binding
CHEMBL4307501
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Inhibition of purified human proteinase 3 using MeOSuc-AAPV-MCA as substrate by fluorescence based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.67 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4560512 | — | — | 1 | 8.21 |
| CHEMBL4557877 | — | — | 1 | 8.15 |
| CHEMBL4528256 | — | — | 1 | 8.01 |
| CHEMBL4455694 | — | — | 1 | 7.77 |
| CHEMBL4589744 | — | — | 1 | 7.64 |
| CHEMBL4470455 | — | — | 1 | 7.29 |
| CHEMBL4469546 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4560512 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL4557877 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4528256 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL4455694 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4589744 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4470455 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL4469546 | — | Ki | = | 245.0 | nM | 6.61 |