Assay Detail
Binding
CHEMBL4307502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human neutrophil elastase using MeOSuc-AAPV-MCA as substrate by fluorescence based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.97 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4557877 | — | — | 1 | 8.49 |
| CHEMBL4560512 | — | — | 1 | 7.80 |
| CHEMBL4455694 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4557877 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL4560512 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4455694 | — | Ki | = | 24.0 | nM | 7.62 |