Assay Detail
Functional
CHEMBL4307516
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Antiplasmodial activity against asexual chloroquine resistant blood stage Plasmodium falciparum Dd2 measured as HRP2 levels after 3 days by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Primaquine homodimers as potential antiplasmodial and anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.31 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | 4.0 | 1 | 5.72 |
| CHEMBL4578273 | — | — | 1 | 4.90 |
| CHEMBL4457829 | — | — | 1 | - |
| CHEMBL4546538 | — | — | 1 | - |
| CHEMBL4578079 | — | — | 1 | - |
| CHEMBL4455575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4578273 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4457829 | — | IC50 | > | 27700.0 | nM | - |
| CHEMBL4546538 | — | IC50 | > | 27700.0 | nM | - |
| CHEMBL4578079 | — | IC50 | > | 27700.0 | nM | - |
| CHEMBL4455575 | — | IC50 | > | 27700.0 | nM | - |