Assay Detail
Functional
CHEMBL4307524
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Antiplasmodial activity against liver stage luciferase expressing Plasmodium berghei sporozoites infected in human Huh7 cells preincubated with host cells for 1 hr followed by plasmodium infection
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Primaquine homodimers as potential antiplasmodial and anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.43 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4546538 | — | — | 1 | 6.70 |
| CHEMBL4472144 | — | — | 1 | 6.45 |
| CHEMBL4457829 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4546538 | — | IC50 | = | 198.1 | nM | 6.70 |
| CHEMBL4472144 | — | IC50 | = | 358.4 | nM | 6.45 |
| CHEMBL4457829 | — | IC50 | = | 726.2 | nM | 6.14 |