Assay Detail
Binding
CHEMBL4308141
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Inhibition of Hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qRT-PCR analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Truncated Itraconazole Analogues Exhibiting Potent Anti-Hedgehog Activity and Improved Drug-like Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.53 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4593633 | — | — | 1 | 7.66 |
| CHEMBL4460173 | — | — | 1 | 7.09 |
| CHEMBL4526458 | — | — | 1 | 7.05 |
| CHEMBL4463913 | — | — | 1 | 6.92 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 1 | 6.85 |
| CHEMBL4572598 | — | — | 1 | 6.80 |
| CHEMBL4533431 | — | — | 1 | 6.80 |
| CHEMBL4471365 | — | — | 1 | 6.66 |
| CHEMBL4463099 | — | — | 1 | 6.64 |
| CHEMBL4550814 | — | — | 1 | 6.58 |
| CHEMBL4559033 | — | — | 1 | 6.58 |
| CHEMBL4456014 | — | — | 1 | 6.55 |
| CHEMBL4461686 | — | — | 1 | 6.44 |
| CHEMBL4549562 | — | — | 1 | 6.42 |
| CHEMBL4435426 | — | — | 1 | 6.34 |
| CHEMBL4578111 | — | — | 1 | 6.33 |
| CHEMBL4560273 | — | — | 1 | 6.24 |
| CHEMBL4458024 | — | — | 1 | 6.24 |
| CHEMBL4520778 | — | — | 1 | 6.24 |
| CHEMBL4581631 | — | — | 1 | 6.06 |
| CHEMBL4466620 | — | — | 1 | 6.02 |
| CHEMBL4573057 | — | — | 1 | 5.89 |
| CHEMBL4462935 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4593633 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4460173 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4526458 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4463913 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4572598 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4533431 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4471365 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4463099 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4550814 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4559033 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4456014 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4461686 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4549562 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4435426 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4578111 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4560273 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4458024 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4520778 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4581631 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4466620 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4573057 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4462935 | — | IC50 | = | 1420.0 | nM | 5.85 |