Assay Detail
Binding
CHEMBL4308175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction of Cd2+ influx preincubated for 5 mins followed by CdCl2 addition by calcium-5 fluorescence dye-based FLIPR assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 6 (CHEMBL1628465) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Photoswitchable Inhibitor of the Calcium Channel TRPV6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.14 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435596 | — | — | 1 | 6.50 |
| CHEMBL4475503 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435596 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4475503 | — | IC50 | = | 1700.0 | nM | 5.77 |