Assay Detail
ADMET
CHEMBL4308347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from full length human cloned 5HT2A receptor expressed in CHO-K1 cells incubated for 1 hr by radioligand displacement assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.61 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440695 | — | — | 1 | 7.64 |
| CHEMBL4454105 | — | — | 1 | 7.04 |
| CHEMBL4463030 | — | — | 1 | 6.78 |
| CHEMBL4470487 | — | — | 1 | 6.74 |
| CHEMBL4434735 | — | — | 1 | 6.69 |
| CHEMBL4569757 | — | — | 1 | 6.68 |
| CHEMBL4457109 | — | — | 1 | 6.58 |
| CHEMBL4465181 | — | — | 1 | 6.55 |
| CHEMBL4473026 | — | — | 1 | 6.51 |
| CHEMBL4540404 | — | — | 1 | 6.49 |
| CHEMBL4456046 | — | — | 1 | 6.47 |
| CHEMBL4464512 | — | — | 1 | 6.44 |
| CHEMBL4462839 | — | — | 1 | 6.04 |
| CHEMBL4592941 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440695 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4454105 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL4463030 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL4470487 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL4434735 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL4569757 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL4457109 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL4465181 | — | Ki | = | 283.0 | nM | 6.55 |
| CHEMBL4473026 | — | Ki | = | 307.0 | nM | 6.51 |
| CHEMBL4540404 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL4456046 | — | Ki | = | 342.0 | nM | 6.47 |
| CHEMBL4464512 | — | Ki | = | 361.0 | nM | 6.44 |
| CHEMBL4462839 | — | Ki | = | 922.0 | nM | 6.04 |
| CHEMBL4592941 | — | Ki | = | 1290.0 | nM | 5.89 |