Assay Detail
ADMET
CHEMBL4308348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]LSD from full length human cloned 5HT6R expressed in HEK293 cells incubated for 1 hr by radioligand displacement assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.37 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463030 | — | — | 1 | 7.28 |
| CHEMBL4440695 | — | — | 1 | 7.24 |
| CHEMBL4470487 | — | — | 1 | 6.98 |
| CHEMBL4465181 | — | — | 1 | 6.88 |
| CHEMBL4454105 | — | — | 1 | 6.80 |
| CHEMBL4464512 | — | — | 1 | 6.43 |
| CHEMBL4457109 | — | — | 1 | 6.34 |
| CHEMBL4569757 | — | — | 1 | 6.04 |
| CHEMBL4456046 | — | — | 1 | 6.04 |
| CHEMBL4540404 | — | — | 1 | 6.01 |
| CHEMBL4462839 | — | — | 1 | 5.90 |
| CHEMBL4473026 | — | — | 1 | 5.79 |
| CHEMBL4434735 | — | — | 1 | 5.76 |
| CHEMBL4592941 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463030 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL4440695 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL4470487 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL4465181 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL4454105 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL4464512 | — | Ki | = | 372.0 | nM | 6.43 |
| CHEMBL4457109 | — | Ki | = | 459.0 | nM | 6.34 |
| CHEMBL4569757 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL4456046 | — | Ki | = | 921.0 | nM | 6.04 |
| CHEMBL4540404 | — | Ki | = | 971.0 | nM | 6.01 |
| CHEMBL4462839 | — | Ki | = | 1272.0 | nM | 5.90 |
| CHEMBL4473026 | — | Ki | = | 1619.0 | nM | 5.79 |
| CHEMBL4434735 | — | Ki | = | 1716.0 | nM | 5.76 |
| CHEMBL4592941 | — | Ki | = | 2352.0 | nM | 5.63 |