Assay Detail
Binding
CHEMBL4308760
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Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.40 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4582324 | — | — | 1 | 7.55 |
| CHEMBL4445994 | — | — | 1 | 7.39 |
| CHEMBL4577049 | — | — | 1 | 7.38 |
| CHEMBL4443654 | — | — | 1 | 7.31 |
| CHEMBL4537527 | — | — | 1 | 7.25 |
| CHEMBL4545269 | — | — | 1 | 7.06 |
| CHEMBL4437906 | — | — | 1 | 6.38 |
| CHEMBL4483095 | — | — | 1 | 5.85 |
| CHEMBL4591137 | — | — | 1 | 5.70 |
| CHEMBL4588040 | — | — | 1 | 5.57 |
| CHEMBL4518970 | — | — | 1 | 5.39 |
| CHEMBL4555519 | — | — | 1 | 5.24 |
| CHEMBL4559531 | — | — | 1 | 5.10 |
| CHEMBL4469360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4582324 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4445994 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4577049 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4443654 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4537527 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4545269 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4437906 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4483095 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4591137 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4588040 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4518970 | — | EC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL4555519 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4559531 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4469360 | — | EC50 | > | 20000.0 | nM | - |