Assay Detail

CHEMBL4308965

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of N-terminally FLAG-tagged mTORC1 (unknown origin) expressed in HEK293T cells using S6K1 or Akt1 as substrate after 20 mins by immunoblotting assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

mTORC1 (CHEMBL4296661) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

mTORC1 (CHEMBL4296661) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target mTORC1

CHEMBL4296661

Anchored from Assay target.

Protein identity mTORC1

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	7 — Homologous single protein target
Curated By	Autocuration

Target

mTORC1 (CHEMBL4296661) ↗

Type	PROTEIN COMPLEX
Organism	Homo sapiens

Publication

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy.

He S, Li Q, Jiang X, Lu X, Feng F, Qu W, Chen Y, Sun H.
J Med Chem (2018) 61 : 4656 -4687
PubMed 29211480 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.70	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1256459	TORIN1	—	1	8.70
CHEMBL1765602	—	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1256459	TORIN1	IC50	=	2.0	nM	8.70
CHEMBL1765602	—	IC50	<	10.0	nM	-