Assay Detail
Binding
CHEMBL4309035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]JNJ-46281222 from human mGlu2 receptor expressed in CHOK1 cell membranes preincubated for 3 hrs followed by [3H]JNJ-46281222 addition and measured after 1 hr by microbeta scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.87 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4589377 | — | — | 1 | 8.38 |
| CHEMBL4538850 | — | — | 1 | 8.21 |
| CHEMBL3947764 | — | — | 1 | 8.12 |
| CHEMBL4468977 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4589377 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL4538850 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL3947764 | — | Ki | = | 7.586 | nM | 8.12 |
| CHEMBL4468977 | — | Ki | = | 165.96 | nM | 6.78 |