Assay Detail
Binding
CHEMBL4309387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDH1 R132H mutant (unknown origin) using alpha-KG as substrate after 90 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Isocitrate dehydrogenase [NADP] cytoplasmic (CHEMBL2007625) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.13 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463644 | — | — | 1 | 8.70 |
| CHEMBL4439421 | — | — | 1 | 8.70 |
| CHEMBL4449563 | — | — | 1 | 7.55 |
| CHEMBL4469739 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463644 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4439421 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4449563 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4469739 | — | IC50 | = | 28.0 | nM | 7.55 |