Assay Detail
Binding
CHEMBL4309422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human KGA (1 to 669 residues) preincubated for 20 mins using 7 mM glutamine as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminase kidney isoform, mitochondrial (CHEMBL2146302) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.09 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177757 | — | — | 1 | 6.72 |
| CHEMBL4456690 | — | — | 1 | 6.41 |
| CHEMBL3664893 | — | — | 1 | 6.34 |
| CHEMBL3664892 | — | — | 1 | 5.97 |
| CHEMBL4452869 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177757 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4456690 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3664893 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3664892 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4452869 | — | IC50 | = | 10200.0 | nM | 4.99 |