Assay Detail
Binding
CHEMBL4309970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.76 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300389 | — | — | 1 | 8.52 |
| CHEMBL1276446 | — | — | 1 | 8.52 |
| CHEMBL261720 | — | — | 1 | 8.52 |
| CHEMBL310840 | — | — | 1 | 8.22 |
| CHEMBL298445 | — | — | 1 | 8.00 |
| CHEMBL409450 | 6BIO | — | 1 | 7.85 |
| CHEMBL319467 | — | — | 1 | 7.66 |
| CHEMBL367625 | — | — | 1 | 7.58 |
| CHEMBL258805 | SU-9516 | 1.0 | 1 | 7.58 |
| CHEMBL411491 | — | — | 1 | 7.51 |
| CHEMBL215919 | — | — | 1 | 7.03 |
| CHEMBL80713 | — | — | 1 | 6.75 |
| CHEMBL393929 | — | — | 1 | 6.73 |
| CHEMBL426972 | — | — | 1 | 6.71 |
| CHEMBL64758 | — | — | 1 | 6.64 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 6.46 |
| CHEMBL3115681 | NARAZACICLIB | 2.0 | 1 | 6.42 |
| CHEMBL477064 | — | — | 1 | 6.30 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 6.27 |
| CHEMBL564829 | MILCICLIB | 2.0 | 1 | 6.23 |
| CHEMBL1802728 | — | — | 1 | 5.96 |
| CHEMBL265964 | — | — | 1 | 5.72 |
| CHEMBL2028998 | — | — | 1 | 5.28 |
| CHEMBL259389 | QUINOXALINE1 | — | 1 | 5.25 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.04 |
| CHEMBL261425 | — | — | 1 | 5.03 |
| CHEMBL132904 | — | — | 1 | 4.84 |
| CHEMBL290904 | — | — | 1 | - |
| CHEMBL1331734 | — | — | 1 | - |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300389 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1276446 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL261720 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL310840 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL298445 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL409450 | 6BIO | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL319467 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL367625 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL258805 | SU-9516 | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL411491 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL215919 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL80713 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL393929 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL426972 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL64758 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL3115681 | NARAZACICLIB | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL477064 | — | IC50 | = | 501.0 | nM | 6.30 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL564829 | MILCICLIB | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1802728 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL265964 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2028998 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL259389 | QUINOXALINE1 | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL261425 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL132904 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL290904 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1331734 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3545110 | RIBOCICLIB | IC50 | > | 20000.0 | nM | - |
| CHEMBL133712 | — | IC50 | > | 20000.0 | nM | - |