Assay Detail
Binding
CHEMBL4310227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged CBP (unknown origin) after 10 mins by TR-FRET assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.25 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436408 | — | — | 1 | 6.25 |
| CHEMBL4436158 | — | — | 1 | - |
| CHEMBL4466746 | — | — | 1 | - |
| CHEMBL4483624 | — | — | 1 | - |
| CHEMBL4518929 | — | — | 1 | - |
| CHEMBL4572531 | — | — | 1 | - |
| CHEMBL4470836 | — | — | 1 | - |
| CHEMBL4463398 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436408 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4436158 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4466746 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4483624 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4518929 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4572531 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4470836 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4463398 | — | IC50 | > | 20000.0 | nM | - |