Assay Detail
Binding
CHEMBL4310494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 7.29 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4522607 | — | — | 1 | 8.10 |
| CHEMBL4451607 | — | — | 1 | 7.89 |
| CHEMBL4444902 | — | — | 1 | 7.85 |
| CHEMBL4451430 | — | — | 1 | 7.66 |
| CHEMBL4447527 | — | — | 1 | 7.60 |
| CHEMBL4548929 | — | — | 1 | 7.58 |
| CHEMBL4448358 | — | — | 1 | 7.57 |
| CHEMBL4454128 | — | — | 1 | 7.47 |
| CHEMBL4514358 | — | — | 1 | 7.37 |
| CHEMBL4517147 | — | — | 1 | 7.35 |
| CHEMBL4537429 | — | — | 1 | 7.33 |
| CHEMBL4453520 | — | — | 1 | 7.30 |
| CHEMBL4569059 | — | — | 1 | 7.23 |
| CHEMBL4465367 | — | — | 1 | 7.23 |
| CHEMBL3134377 | — | — | 1 | 7.21 |
| CHEMBL4440004 | — | — | 1 | 7.18 |
| CHEMBL4516248 | — | — | 1 | 7.17 |
| CHEMBL4440870 | — | — | 1 | 7.04 |
| CHEMBL4437380 | — | — | 1 | 7.00 |
| CHEMBL4581929 | — | — | 1 | 6.96 |
| CHEMBL4530322 | — | — | 1 | 6.96 |
| CHEMBL4591673 | — | — | 1 | 6.85 |
| CHEMBL4437892 | — | — | 1 | 6.85 |
| CHEMBL4527219 | — | — | 1 | 6.82 |
| CHEMBL4560537 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4522607 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4451607 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4444902 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4451430 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4447527 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4548929 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4448358 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4454128 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4514358 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4517147 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4537429 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4453520 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4569059 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4465367 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3134377 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4440004 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4516248 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4440870 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4437380 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4581929 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4530322 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4591673 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4437892 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4527219 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4560537 | — | EC50 | = | 160.0 | nM | 6.80 |