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Assay Detail

CHEMBL4310853

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Potentiation of vincristine-induced cytotoxicity against human KBV cells assessed as vincristine IC50 at 10 uM after 48 hrs by MTT assay (Rvb = 666.3 nM)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Seco-4-methyl-DCK derivatives as potent chemosensitizers.
Guo Y, Wang K, Chen X, Li H, Wan Q, Morris-Natschke S, Lee KH, Chen Y.
Bioorg Med Chem Lett (2019) 29 : 28 -31
PubMed 30455148 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 8.84 9.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4522326 1 9.28
CHEMBL4581922 1 9.08
CHEMBL6966 VERAPAMIL 4.0 1 8.88
CHEMBL4567989 1 8.67
CHEMBL4579739 1 8.30
CHEMBL4447443 1 -
CHEMBL4546824 1 -
CHEMBL4434747 1 -
CHEMBL4522853 1 -
CHEMBL4475162 1 -
CHEMBL4460036 1 -
CHEMBL4576678 1 -
CHEMBL4443130 1 -
CHEMBL4473953 1 -
CHEMBL4470106 1 -
CHEMBL4441122 1 -
CHEMBL4450018 1 -
CHEMBL4465433 1 -
CHEMBL4538971 1 -
CHEMBL4555775 1 -
CHEMBL4434961 1 -
CHEMBL4436690 1 -
CHEMBL4562930 1 -
CHEMBL4455155 1 -
CHEMBL4517233 1 -
CHEMBL428647 PACLITAXEL 4.0 1 -
CHEMBL4547021 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4522326 IC50 = 0.53 nM 9.28
CHEMBL4581922 IC50 = 0.84 nM 9.08
CHEMBL6966 VERAPAMIL IC50 = 1.31 nM 8.88
CHEMBL4567989 IC50 = 2.12 nM 8.67
CHEMBL4579739 IC50 = 4.99 nM 8.30
CHEMBL4447443 IC50 - -
CHEMBL4546824 IC50 - -
CHEMBL4434747 IC50 - -
CHEMBL4522853 IC50 - -
CHEMBL4475162 IC50 - -
CHEMBL4460036 IC50 - -
CHEMBL4576678 IC50 - -
CHEMBL4443130 IC50 - -
CHEMBL4473953 IC50 - -
CHEMBL4470106 IC50 - -
CHEMBL4441122 IC50 - -
CHEMBL4450018 IC50 - -
CHEMBL4465433 IC50 - -
CHEMBL4538971 IC50 - -
CHEMBL4555775 IC50 - -
CHEMBL4434961 IC50 - -
CHEMBL4436690 IC50 - -
CHEMBL4562930 IC50 - -
CHEMBL4455155 IC50 - -
CHEMBL4517233 IC50 - -
CHEMBL428647 PACLITAXEL IC50 - -
CHEMBL4547021 IC50 - -