Assay Detail

CHEMBL4311524

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Binding

Inhibition of recombinant human Aurora A

ChEMBL ↗

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Target

Aurora kinase A (CHEMBL4722) ↗

Open DB target context

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Primary target Aurora kinase A

CHEMBL4722

Anchored from Assay target.

Protein identity Aurora kinase A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Aurora kinase A (CHEMBL4722) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Synthesis and identification of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential Aurora A inhibitors.

Sang CY, Qin WW, Zhang XJ, Xu Y, Ma YZ, Wang XR, Hui L, Chen SW.
Bioorg Med Chem (2019) 27 : 65 -78
PubMed 30502115 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.85	7.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL482968	ENMD-2076	2.0	1	7.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL482968	ENMD-2076	IC50	=	14.0	nM	7.85