Assay Detail
Binding
CHEMBL4311604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant N-terminal His6x-tagged human CA14 (20 to 280 residues) catalytic domain expressed in Escherichia coli Rosetta 2 (DE3) by DSF-based fluorescence thermal shift assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrrolidinone-bearing methylated and halogenated benzenesulfonamides as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 51 | 6.23 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463683 | — | — | 1 | 7.92 |
| CHEMBL4458989 | — | — | 1 | 7.40 |
| CHEMBL4567746 | — | — | 1 | 7.02 |
| CHEMBL4474251 | — | — | 1 | 6.70 |
| CHEMBL4444784 | — | — | 1 | 6.33 |
| CHEMBL4446249 | — | — | 1 | 6.14 |
| CHEMBL4465027 | — | — | 1 | 6.08 |
| CHEMBL4593434 | — | — | 1 | 6.04 |
| CHEMBL4474833 | — | — | 1 | 5.70 |
| CHEMBL4439909 | — | — | 1 | 5.50 |
| CHEMBL4577083 | — | — | 1 | 5.41 |
| CHEMBL4454574 | — | — | 1 | 5.40 |
| CHEMBL4449430 | — | — | 1 | 5.30 |
| CHEMBL4439634 | — | — | 1 | - |
| CHEMBL4441730 | — | — | 1 | - |
| CHEMBL4448119 | — | — | 1 | - |
| CHEMBL2362604 | — | — | 1 | - |
| CHEMBL4570038 | — | — | 1 | - |
| CHEMBL4462447 | — | — | 1 | - |
| CHEMBL4553790 | — | — | 1 | - |
| CHEMBL4516072 | — | — | 1 | - |
| CHEMBL4555586 | — | — | 1 | - |
| CHEMBL4558457 | — | — | 1 | - |
| CHEMBL4577993 | — | — | 1 | - |
| CHEMBL4556132 | — | — | 1 | - |
| CHEMBL4475283 | — | — | 1 | - |
| CHEMBL4436955 | — | — | 1 | - |
| CHEMBL4539399 | — | — | 1 | - |
| CHEMBL4573073 | — | — | 1 | - |
| CHEMBL4539340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463683 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4458989 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL4567746 | — | Kd | = | 96.0 | nM | 7.02 |
| CHEMBL4474251 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL4444784 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL4446249 | — | Kd | = | 720.0 | nM | 6.14 |
| CHEMBL4465027 | — | Kd | = | 840.0 | nM | 6.08 |
| CHEMBL4593434 | — | Kd | = | 910.0 | nM | 6.04 |
| CHEMBL4474833 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL4439909 | — | Kd | = | 3200.0 | nM | 5.50 |
| CHEMBL4577083 | — | Kd | = | 3900.0 | nM | 5.41 |
| CHEMBL4454574 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL4449430 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL4473602 | — | Kd | - | — | - | |
| CHEMBL4464359 | — | Kd | - | — | - | |
| CHEMBL4587295 | — | Kd | - | — | - | |
| CHEMBL4573916 | — | Kd | - | — | - | |
| CHEMBL4560953 | — | Kd | - | — | - | |
| CHEMBL4555622 | — | Kd | - | — | - | |
| CHEMBL4443078 | — | Kd | - | — | - | |
| CHEMBL4475315 | — | Kd | - | — | - | |
| CHEMBL4558235 | — | Kd | - | — | - | |
| CHEMBL4517728 | — | Kd | - | — | - | |
| CHEMBL4567916 | — | Kd | - | — | - | |
| CHEMBL4516858 | — | Kd | - | — | - | |
| CHEMBL4449149 | — | Kd | - | — | - | |
| CHEMBL4461481 | — | Kd | - | — | - | |
| CHEMBL4590754 | — | Kd | - | — | - | |
| CHEMBL4570253 | — | Kd | - | — | - | |
| CHEMBL4457904 | — | Kd | - | — | - | |
| CHEMBL1450580 | — | Kd | - | — | - | |
| CHEMBL4516072 | — | Kd | - | — | - | |
| CHEMBL4539340 | — | Kd | - | — | - | |
| CHEMBL4573073 | — | Kd | - | — | - | |
| CHEMBL4539399 | — | Kd | - | — | - | |
| CHEMBL4436955 | — | Kd | - | — | - | |
| CHEMBL4475283 | — | Kd | - | — | - | |
| CHEMBL4556132 | — | Kd | - | — | - | |
| CHEMBL4577993 | — | Kd | - | — | - | |
| CHEMBL4558457 | — | Kd | - | — | - | |
| CHEMBL4555586 | — | Kd | - | — | - | |
| CHEMBL4441652 | — | Kd | - | — | - | |
| CHEMBL4553790 | — | Kd | - | — | - | |
| CHEMBL4462447 | — | Kd | - | — | - | |
| CHEMBL4570038 | — | Kd | - | — | - | |
| CHEMBL2362604 | — | Kd | - | — | - | |
| CHEMBL4448119 | — | Kd | - | — | - | |
| CHEMBL4441730 | — | Kd | - | — | - | |
| CHEMBL4439634 | — | Kd | - | — | - | |
| CHEMBL4452277 | — | Kd | - | — | - |