Assay Detail
Binding
CHEMBL4311614
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Binding affinity to recombinant human CA12 assessed as intrinsic dissociation constant by DSF-based fluorescence thermal shift assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrrolidinone-bearing methylated and halogenated benzenesulfonamides as inhibitors of carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 36 | 8.92 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4517728 | — | — | 1 | 9.82 |
| CHEMBL4464359 | — | — | 1 | 9.74 |
| CHEMBL4539340 | — | — | 1 | 9.62 |
| CHEMBL4577993 | — | — | 1 | 9.49 |
| CHEMBL4463683 | — | — | 1 | 9.43 |
| CHEMBL4516858 | — | — | 1 | 9.32 |
| CHEMBL4439909 | — | — | 1 | 9.31 |
| CHEMBL4446249 | — | — | 1 | 9.31 |
| CHEMBL4567916 | — | — | 1 | 9.28 |
| CHEMBL4452277 | — | — | 1 | 9.22 |
| CHEMBL4474251 | — | — | 1 | 9.21 |
| CHEMBL4558457 | — | — | 1 | 9.20 |
| CHEMBL4475315 | — | — | 1 | 9.16 |
| CHEMBL4555622 | — | — | 1 | 9.16 |
| CHEMBL4573916 | — | — | 1 | 9.02 |
| CHEMBL4461481 | — | — | 1 | 9.02 |
| CHEMBL4593434 | — | — | 1 | 9.01 |
| CHEMBL4567746 | — | — | 1 | 9.01 |
| CHEMBL4558235 | — | — | 1 | 8.96 |
| CHEMBL4553790 | — | — | 1 | 8.96 |
| CHEMBL4590754 | — | — | 1 | 8.85 |
| CHEMBL4560953 | — | — | 1 | 8.85 |
| CHEMBL4516072 | — | — | 1 | 8.77 |
| CHEMBL4474833 | — | — | 1 | 8.74 |
| CHEMBL4443078 | — | — | 1 | 8.68 |
| CHEMBL4577083 | — | — | 1 | 8.62 |
| CHEMBL4444784 | — | — | 1 | 8.57 |
| CHEMBL4465434 | — | — | 1 | 8.51 |
| CHEMBL4462447 | — | — | 1 | 8.51 |
| CHEMBL4449430 | — | — | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4517728 | — | Kd | = | 0.15 | nM | 9.82 |
| CHEMBL4464359 | — | Kd | = | 0.18 | nM | 9.74 |
| CHEMBL4539340 | — | Kd | = | 0.24 | nM | 9.62 |
| CHEMBL4577993 | — | Kd | = | 0.32 | nM | 9.49 |
| CHEMBL4463683 | — | Kd | = | 0.37 | nM | 9.43 |
| CHEMBL4516858 | — | Kd | = | 0.48 | nM | 9.32 |
| CHEMBL4439909 | — | Kd | = | 0.49 | nM | 9.31 |
| CHEMBL4446249 | — | Kd | = | 0.49 | nM | 9.31 |
| CHEMBL4567916 | — | Kd | = | 0.53 | nM | 9.28 |
| CHEMBL4452277 | — | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL4474251 | — | Kd | = | 0.61 | nM | 9.21 |
| CHEMBL4558457 | — | Kd | = | 0.63 | nM | 9.20 |
| CHEMBL4475315 | — | Kd | = | 0.69 | nM | 9.16 |
| CHEMBL4555622 | — | Kd | = | 0.69 | nM | 9.16 |
| CHEMBL4461481 | — | Kd | = | 0.96 | nM | 9.02 |
| CHEMBL4573916 | — | Kd | = | 0.96 | nM | 9.02 |
| CHEMBL4593434 | — | Kd | = | 0.98 | nM | 9.01 |
| CHEMBL4567746 | — | Kd | = | 0.98 | nM | 9.01 |
| CHEMBL4558235 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4553790 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4590754 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL4560953 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL4516072 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL4474833 | — | Kd | = | 1.8 | nM | 8.74 |
| CHEMBL4443078 | — | Kd | = | 2.1 | nM | 8.68 |
| CHEMBL4577083 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL4444784 | — | Kd | = | 2.7 | nM | 8.57 |
| CHEMBL4465434 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL4462447 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL4449430 | — | Kd | = | 3.2 | nM | 8.49 |
| CHEMBL4465027 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL4555586 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL4449149 | — | Kd | = | 4.2 | nM | 8.38 |
| CHEMBL4454574 | — | Kd | = | 6.2 | nM | 8.21 |
| CHEMBL4570038 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4448119 | — | Kd | = | 12.0 | nM | 7.92 |