Assay Detail
Binding
CHEMBL4312389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N-terminal tagged human HDAC6 expressed in HEK293T/17 using Ac-Gly-Ala-[Ac-Lys]-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 15 mins by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.24 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 8.42 |
| CHEMBL4465902 | — | — | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4465902 | — | IC50 | = | 8.7 | nM | 8.06 |