Assay Detail
Functional
CHEMBL4312420
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Antiproliferative activity against human MM1S cells assessed as reduction in cell viability measured after 72 hrs by resazurin dye based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.44 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458338 | — | — | 1 | 7.75 |
| CHEMBL4465902 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458338 | — | EC50 | = | 17.7 | nM | 7.75 |
| CHEMBL4465902 | — | EC50 | = | 74.9 | nM | 7.13 |