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Assay Detail

CHEMBL4312935

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to full-length human PRDX1 by surface plasmon resonance analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peroxiredoxin-1 (CHEMBL5315)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
Zhou X, Liang Z, Li K, Fang W, Tian Y, Luo X, Chen Y, Zhan Z, Zhang T, Liao S, Liu S, Liu Y, Fenical W, Tang L.
J Med Chem (2019) 62 : 7058 -7069
PubMed 31298537 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 5.66 5.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4092369 1 5.74
CHEMBL272733 PIERICIDIN A 1 5.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4092369 Kd = 1830.0 nM 5.74
CHEMBL272733 PIERICIDIN A Kd = 2610.0 nM 5.58