Assay Detail

CHEMBL4313157

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to 6-FAM-5'-CAGCGCTCGG(20T)CCGAGCGCTG-3'-dabcyl DNA (unknown origin) by spectrofluorimetric method

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Not specified
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.

Elmenoufy AH, Gentile F, Jay D, Karimi-Busheri F, Yang X, Soueidan OM, Weilbeer C, Mani RS, Barakat KH, Tuszynski JA, Weinfeld M, West FG.
J Med Chem (2019) 62 : 7684 -7696
PubMed 31369707 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	5.68	5.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4470176	—	—	1	5.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4470176	—	Kd	=	2100.0	nM	5.68