Assay Detail
Functional
CHEMBL4313188
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Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.71 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473374 | — | — | 1 | 5.85 |
| CHEMBL4442689 | — | — | 1 | 5.82 |
| CHEMBL4474803 | — | — | 1 | 5.77 |
| CHEMBL4540180 | — | — | 1 | 5.40 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473374 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4442689 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4474803 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4540180 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | > | 15000.0 | nM | - |