Assay Detail
Functional
CHEMBL4313575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.03 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472670 | — | — | 1 | 7.40 |
| CHEMBL4459432 | — | — | 1 | 7.00 |
| CHEMBL4463939 | — | — | 1 | 6.46 |
| CHEMBL4541423 | — | — | 1 | 6.39 |
| CHEMBL4559879 | — | — | 1 | 6.28 |
| CHEMBL4472082 | — | — | 1 | 6.25 |
| CHEMBL4469366 | — | — | 1 | 6.24 |
| CHEMBL4530425 | — | — | 1 | 6.17 |
| CHEMBL4570545 | — | — | 1 | 6.15 |
| CHEMBL4553392 | — | — | 1 | 6.12 |
| CHEMBL4579484 | — | — | 1 | 6.05 |
| CHEMBL4438232 | — | — | 1 | 6.00 |
| CHEMBL4529269 | — | — | 1 | 5.83 |
| CHEMBL4528338 | — | — | 1 | 5.80 |
| CHEMBL4573516 | — | — | 1 | 5.67 |
| CHEMBL4469552 | — | — | 1 | 5.65 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.62 |
| CHEMBL4529613 | — | — | 1 | 5.55 |
| CHEMBL4455365 | — | — | 1 | 5.15 |
| CHEMBL4578672 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472670 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4459432 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4463939 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4541423 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4559879 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4472082 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4469366 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4530425 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4570545 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4553392 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4579484 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4438232 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4529269 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4528338 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4573516 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL4469552 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL4529613 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL4455365 | — | IC50 | = | 7110.0 | nM | 5.15 |
| CHEMBL4578672 | — | IC50 | = | 12730.0 | nM | 4.89 |