Assay Detail
Functional
CHEMBL4313745
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Antiproliferative activity against human KBVIN cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.19 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.50 |
| CHEMBL337173 | — | — | 1 | 5.31 |
| CHEMBL4521092 | — | — | 1 | 5.17 |
| CHEMBL4466461 | — | — | 1 | 5.04 |
| CHEMBL4566962 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3145.83 | nM | 5.50 |
| CHEMBL337173 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL4521092 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL4466461 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL4566962 | — | IC50 | = | 11620.0 | nM | 4.93 |